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Progress in Cell Cycle Research by Anne Op De Beeck, Perrine Caillet-Fauquet (auth.), Laurent

By Anne Op De Beeck, Perrine Caillet-Fauquet (auth.), Laurent Meijer, Silvana Guidet, Michel Philippe (eds.)

The "Progress in cellphone Cycle learn" sequence has been conceived to function a suite of experiences on a number of elements of a quick becoming biology box, the mobile department cycle. those reports don't faux to hide all points of telephone cycle law and mechanisms yet quite specialize in a couple of subject matters of specific curiosity within the fresh literature. This 3rd quantity starts off with a extensive assessment of the range of the way during which viruses subdue their host cellphone cycle (chapter 1). Of specific curiosity during this zone is the case of HN which has lately been generally investigated (chapter 2). even if so much of our realizing of mobilephone cycle law derives from paintings played in yeast and animal cells, plant versions, reviewed in bankruptcy three for the best studied instance, Arabidopsis, are beginning to give a contribution considerably to the mobilephone cycle basic photo. In mammals, the law of mobilephone department of 2 forms of tissues, the gut (chapter four) and the constructing muscle (chapter five) are investigated in an enticing physiological context. mobilephone department is followed through a few morphological alterations. one in every of them, organelle delivery, is transforming into higher understood (chapter 6). the following few bankruptcy summarise our wisdom of a few crucial regulators of the phone cycle. A nonetheless exciting enzyme, casein kinase 2, is reviewed intimately in bankruptcy 7. one of the most studied cellphone cycle regulators are definitely the CKI's, cyclin-dependent kinases inhibitors (chapter 8).

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Not a single CDK inhibitor protein (CKI) has yet been characterised geneticalIy or biochemicalIy in plants. The only indication that CKIs may be employed in plant celIs was provided by the work of Grafi and Larkins (61), who showed that cells of maize endosperm undergoing endoreduplication contain an unidentified active inhibitor of the HI kinase activity of mitotically dividing endosperm cells. Finally, it is known that the function of plant CDKs is also regulated by differential subcelIular localisation in the course of the celI cycle.

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VAN MONTAGU AND D. INZE Gl. The 12 cyclins identified in A. thaliana represent the A2, Bl, B2, 01, D2, and D3 groups (see Table 1). identified on the basis of sequence homology in diverse plant species. It is now clear that a few distinct classes of CDKs are present in plants (9). In A. thaliana, two CDKs have been characterised so far, Cdc2aAt and Cdc2bAt (10, 11). [The nomenclature of plant CDKs used in ref. 9 has been adopted in this review]. Cdc2aAt is a representative of the most abundant group of plant CDKs, comprising by now at least 13 members from nine species ("group A" according to ref.

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