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Applications of polymers in drug delivery by Ambikanandan Misra, Aliasgar Shahiwala

By Ambikanandan Misra, Aliasgar Shahiwala

Use of polymers has turn into critical within the box of drug supply. Polymers play a vital position in modulating drug supply to use greatest healing merits and feature been primary within the profitable improvement of a number of novel drug supply structures which are now available.

This e-book offers information of the functions of polymeric drug supply structures that may be of curiosity to researchers in industries and academia. It describes the advance of polymeric platforms starting from the traditional dosage kinds as much as the newest clever structures. The regulatory and highbrow estate features in addition to the scientific applicability of polymeric drug supply platforms also are discussed.

Each various drug supply path is mentioned in a separate bankruptcy of the e-book. All significant routes of drug supply were coated to supply the reader with a wide ranging in addition to an in-depth view of the advancements in polymer-based drug supply platforms. Appendices are incorporated which comprise priceless pharmaceutical homes of the polymers and critical polymeric purposes for numerous drug supply routes.

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For example, a partially neutralised PAA complex was developed in the presence of levobetaxolol hydrochloride, a potent cardiac β-blocker. The delivery system was prone to dissolution due to the release of the incorporated drug as the time progressed [69]. , by using orifice ionic gelation. The technique has been used to design a delivery system of gliclazide, an anti-diabetic drug, using sodium alginate, sodium CMC, Carbopol® 934P and HPMC. The delivery system showed the release of gliclazide for an extended period of time due to its mucoadhesive properties [70].

The dimensions and position of the plug inside the capsule can control the lag-time. For rapid release of water insoluble drug effervescent or disintegrating agents are added. , polymethacrylates). , HPMC, PVA). , glyceryl monooleate). , pectin). 3 Ion-Exchange Based Drug Delivery System Ion exchange resins are insoluble polymers that contain acidic or basic functional groups and have the ability to exchange counter-ions within aqueous solutions surrounding them. An ion exchange resin is an insoluble matrix normally in the form of small beads of 1-2 mm diameter, usually white or yellowish, fabricated from an organic polymer substrate backbone [54].

One application of this targeting approach is the delivery of drugs to the colon, and site-specific cleavage is ensured by the presence of linkages that are only degraded by bacteria present in that part of the GIT [33]. 3 Biodegradable/Degradation and Erosion Controlled Systems A major disadvantage with non-biodegradable polymers is that a surgery is required to harvest these polymers out of the body once they are depleted of the drug. Thus, non-biodegradable polymers can be used only if removal of the implant is easy (such as an ocular implant).

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