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Age-Related Macular Degeneration by D. Virgil Alfaro III et al.

By D. Virgil Alfaro III et al.

Stay brand new with the newest advancements on your box with the highly-anticipated moment variation of Age-Related Macular Degeneration. This complete textual content covers contemporary advances in pathophysiology, prognosis, and therapy together with promising new advancements that would have an effect on your sufferer care. Dr. Virgil Alfaro and his colleagues at Retina specialists of Charleston deliver you their services within the components of easy technology, imaging, prevention, therapy, and more.

Features:
  • Learn from a well known workforce of retina surgeons who deal with all points of administration, together with anatomy, body structure, and pathophysiology; imaging of the macula in ARMD, prevention measures and therapy; and destiny instructions within the field.
  • Gain a superb origin in intravenous fluorescein angiography, indocyanine eco-friendly angiography, and optical coherence tomography, in addition to antiVEGE treatment and comparable new medicines, optimizing your prognosis and therapy options.
  • Understand the numerous switch within the class process of choroidal neovascular membranes in ARMD.
  • Get up to date details on treating ARMD secondary to geographic atrophy via cellphone transplantation and pharmacologic therapies.
  • Easily visualize key elements of ARMD due to top quality illustrations and photographs.
  • Find the knowledge you would like fast through referencing person chapters that provide finished and inclusive insurance of the subject at hand.
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Age-Related Macular Degeneration

Stay awake thus far with the newest advancements on your box with the highly-anticipated moment variation of Age-Related Macular Degeneration. This accomplished textual content covers fresh advances in pathophysiology, prognosis, and remedy together with promising new advancements that may impact your sufferer care.

Additional resources for Age-Related Macular Degeneration

Example text

Used Matrigel injection to assess the necessity of a proper relationship between the RPE and BM so as (c) 2015 Wolters Kluwer. All Rights Reserved. Chapter 2 Animal Models for Age-Related Macular Degeneration 27 to prevent abnormal ­angiogenesis. Matrigel was injected to the subretinal space of rats to create an amorphous deposit, causing RPE cells to migrate toward photoreceptors and then form a new layer between the deposit and photoreceptors, resulting in RPE translocation. The BM devoid of RPE attachment becomes susceptible to invasion by new blood vessels from the choroid, thereby resulting in CNV (241).

This lesion, known as retinal angiomatous proliferation, can be present as part of advanced AMD in humans, and it holds a poor prognosis. Advantages of the primate model include the close approximation of the monkey retina and macula to the human, size of the primate eye for drug delivery studies, (c) 2015 Wolters Kluwer. All Rights Reserved. 26 SECTION 1 ANATOMY, PHYSIOLOGY, AND PATHOLOGY OF THE MACULA and utility of the model for development of human clinical trials. Disadvantages include the expense of the animals, animal care and husbandry, length of experiments, and ethical issues regarding use of primates when rodents (mice and rats) are a reliable model.

Symptoms appeared as early as 2 years of age and exacerbate gradually with aging. While funduscopy revealed fine, yellowish white dots within the macula of affected animals, drusen from these animals have been confirmed by histopathology to closely resemble human equivalents and have been shown by immunohistochemistry and proteomic analysis to contain many human hallmarks, such as: ■■ Apolipoprotein E ■■ Amyloid P component ■■ Various-sized complement component C5 ■■ The terminal C5b-9 complement complex ■■ Vitronectin, membrane cofactor protein ■■ Annexins ■■ Crystallins ■■ Immunoglobulins Young age of onset and inheritance pattern in this model are reminiscent of a number of early-onset maculopathies in humans, rather than AMD.

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