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A History of Gastric Secretion and Digestion: Experimental by Horace W. Davenport

By Horace W. Davenport

This ebook examines the heritage of experimental learn in gastric secretion and digestion. the writer identifies the medical questions that experience occupied researchers and discusses the experiments that experience ended in their suggestions. by way of setting apart elements of experimental examine and tracing their evolution through the years, the ebook presents gastric physiologists and gastroenterologists with a great figuring out of the highbrow heritage in their box.

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From Hollander F. The composition of pure gastric juice. ) -e .... ; u :I: d ea.. /20 min. Figure 1-6. The relation between volume-rate of gastric secretion by dogs and the concentrations of "chloride fractions" in pooled samples. (From Gray JS, Bucher GR, Harman HH. The relationships between total acid and neutral chlorides of gastric juice. ) Table 1-2. 6 Source: Compiled from data in Gray JS, Bucher, GR, The composition ofgastric juice as a function of the rate of secretion. Am J Physiol 133:542-550, 1941.

Isotopes of sodium, potassium, and carbon gave him data for calculating the unidirectional fluxes ofthe two cations and ofbicarbonate. Hagben measured the potential difference between the two sides of the tissue by means of calomel electrodes, and with a circuit generating current, he could set the potential difference at any value. When he set the potential difference at zero, the current required to do this, the short-circuit current expressed in JLEQ cm - 2hr- 1, was the current generated by mucosal transport ofions.

When N. U. Meldrum and F. J. W. Roughton found carbonic anhydrase in erythrocytes, they failed to find it in the starnach for reasons that have nothing to do with Iabaratory work. 100 In late May 1938 R. B. Fisher, persuaded by observationssuch as those ofBrown and Vineberg that the stomach's ability to secrete acid is influenced by the carbon dioxide in the blood, 101 attempted to persuade me to Iook for carbonic anhydrase in the gastric mucosa. I found it in the first week of June 1938, and the next week I learned Meldrum and Roughton's method for measuring carbonic anhydrase in Cambridge.

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